Laboratory of Mucosal ImmunologyIn the Department of Medicine and Pediatrics
Director: Dr. Martin Kagnoff

About our Lab

About our Lab

The Laboratory of Mucosal Immunology was established at the University of California, San Diego in 1985. The main focus of the Laboratory of Mucosal Immunology is to investigate biochemical mechanisms that are required for the initiation and maintenance of mucosal inflammation and immunity. The lab studies mechanisms that are required for the initiation and maintenance of mucosal inflammation and immunity. These studies include research on intestinal inflammatory diseases such as celiac disease, ulcerative colitis and Crohn's disease and gastrointestinal infections with disease caused by microbial and viral pathogens.

Immune responses at mucosal surfaces play a major role in host mucosal defense against microbial pathogens and in the pathogenesis of acute and chronic mucosal inflammatory diseases. The laboratory draws on a broad spectrum of molecular, biochemical, and immunogenetic techniques in combination with the usage of human and murine in-vitro cell cultures using in-vivo model systems to address questions in mucosal immunity.

Through this techniques, the lab hopes reveal the biochemical relationship between enteroinvasive viruses and bacteria, the intestinal epithelium and mucosal immune cells. Laboratory members are defining novel signaling pathways that are activated in by pathogen invasion and the activation of regulated host gene programs by these pathogens.

Ultimately our lab focus on primarily two topics of mucosal immunology:
  • Studies of mechanisms by which microbial pathogens alter epithelial cell function.
  • Studies of crosstalk between epithelial cells and mucosal lymphoid cells.

The Laboratory of Mucosal Immunology is associated with School of Medicine Graduate Training Programs in Biomedical Sciences. This Lab is also associated with both The UCSD Cancer Center and a NIH Training Program in Intestinal Diseases.

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